Restoration of Oligodendrocyte Pools in a Mouse Model of Chronic Cerebral Hypoperfusion
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منابع مشابه
Restoration of Oligodendrocyte Pools in a Mouse Model of Chronic Cerebral Hypoperfusion
Chronic cerebral hypoperfusion, a sustained modest reduction in cerebral blood flow, is associated with damage to myelinated axons and cognitive decline with ageing. Oligodendrocytes (the myelin producing cells) and their precursor cells (OPCs) may be vulnerable to the effects of hypoperfusion and in some forms of injury OPCs have the potential to respond and repair damage by increased prolifer...
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BACKGROUND AND PURPOSE We recently designed a mouse model of chronic cerebral hypoperfusion, in which the cerebral white matter is damaged without significant gray matter lesions. The behavioral characteristics of these mice were studied using a test battery for neurological and cognitive functions. METHODS Adult C57Bl/6 male mice were subjected to either sham-operation or bilateral common ca...
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BACKGROUND AND PURPOSE Cerebrovascular white matter (WM) lesions are closely associated with cognitive impairment and gait disorders in the elderly. We have successfully established a mouse model of chronic cerebral hypoperfusion that may provide new strategies for the molecular analysis of cerebrovascular WM lesions. METHODS Adult C57Bl/6 male mice were subjected to bilateral common carotid ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0087227